We identified arachidonic acid as an important phospholipid component in the adrenal gland. In the present study we investigated how the lipid landscape of the adrenal gland changes upon diet-induced obesity and whether these changes are involved in the regulation of adrenal hormone synthesis. Moreover, the chain length and saturation of lipid species in the adipose tissue and liver, as well as the serum lipidome substantially change during obesity. triacylglycerides (TAG) in these tissues. However, the mechanisms underlying adrenal function alterations during obesity remain largely obscure.Ī feature of obesity is dysregulation of lipid homeostasis in tissues, such as the adipose tissue and liver, resulting in accumulation of storage lipids, i.e. Moreover, elevated aldosterone and glucocorticoid levels can promote insulin resistance. Circulating glucocorticoids, which can promote abdominal fat deposition, are also elevated in animal models of obesity. Aldosterone, the major regulator of blood volume and pressure, is increased in the circulation in obesity, which can cause hypertension and cardiovascular disease. Elevated adrenal hormone levels are observed in obesity and could contribute to the development of obesity-associated pathologies. Obesity increases the risk for type 2 diabetes mellitus, non-alcoholic steatohepatitis and cardiovascular diseases.
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